Methylation

DNA methylation is a biochemical process that is important for normal development and a wide range of biological processes.

Introduction 

DNA methylation is a biochemical process that is important for normal development and a wide range of biological processes.

It is a heritable modification that regulates gene expression without altering the DNA sequence. Therefore, aberrant methylation patterns have been associated with certain cancers.

CpG and promoter microarrays enable analysis of methylation events. Methylated DNA regions on the genome can be mapped using a combination of affinity-based enrichment, such as methylated DNA immunoprecipitation (MeDIP) or the methylated CpG island recovery assay (MIRA), followed by microarray analysis.