EPCAM

Description 
epithelial cell adhesion molecule adenocarcinoma-associated antigen cell surface glycoprotein-2 epithelial glycoprotein 314 human epithelial glycoprotein-2 major gastrointestinal tumor-associated protein GA733-2 membrane component, chromosome 4, surface maker (35kD glycoprotein) tumor-associated calcium signal transducer 1

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins.

This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule.

The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Aliases 
DIAR5, EGP-2, EGP314, EGP40, ESA, GA733-2, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1
Chromosomal Locations 
2p21