Please be on the look out for
Ambry Representatives at :
American Society of Human Genetics
(ASHG) 64th Annual Meeting
Booth Number # 1131
San Diego Convention Center
San Diego, CA
10/18/14 - 10/22/14
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins.
This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule.
The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.