This gene is composed of 2 exons and codes for a protein that belongs in the potassium channel KCNE family. The kcne2 protein subunit associates with kcnh2 and forms an ion transport channel that is responsible for repolarizing the heart muscles after contraction. The kcne2 protein’s function is to regulate the activity of a potassium channel that it forms with kcnh2. Mutations in this gene are associated with cardiac arrhythmia and LongQT syndrome (LQTS).