MYH7

Description 
myosin, heavy chain 7, cardiac muscle, beta


MYH7 (NM_000257.2) encodes beta myosin heavy chain, a subunit of the hexameric cardiac muscle myosin protein.  Cardiac muscle myosin functions as part of the sarcomere to generate the mechanical force required for muscle contraction.  The MYH7 gene is located at 14q11.2-q12 and is composed of 38 coding exons.  Mutations in MYH7 account for 5-8% of dilated cardiomyopathy, and approximately 40% of hypertrophic cardiomyopathy.  In addition, mutations in MYH7 can cause left ventricular non-compaction and skeletal myopathies with and without cardiac involvement (Hershberger et alCirc Heart Fail. 2009;253-261; Walsh et alCardiology. 2010;115:49–60).  

Aliases 
CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM
Chromosomal Locations 
14q11.2-q12