PTPN11

Description 
protein tyrosine phosphatase, non-receptor type 11 PTP-2C protein tyrosine phosphatase-2 protein-tyrosine phosphatase 1D protein-tyrosine phosphatase 2C tyrosine-protein phosphatase non-receptor type 11


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.

Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Aliases 
BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Chromosomal Locations 
12q24