Methylation Analysis

Methylation analysis is a technique that identifies areas of DNA that have been methylated, which is a DNA modification that typically suppresses gene transcription.

Introduction 

Methylation analysis is a technique that identifies areas of DNA that have been methylated, which is a DNA modification that typically suppresses gene transcription.

DNA methylation occurs when methyl groups are added to DNA, which typically suppresses gene function. DNA methylation is essential for normal development and many biological processes, including genomic imprinting, X chromosome inactivation, suppression of repetitive elements, and malignancy. Methylation analysis detects the presence or absence of these methyl groups on specific regions of DNA.

At Ambry, methylation analysis is performed using methylation sensitive PCR analysis (mPCR) for specific disease testing.