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Concordance of Germline Multigene Panel Testing with Prior Microsatellite Instability and Immunohistochemistry Analyses in Endometrial Cancer Patients

Session:
#9846
Date:
Sunday, Mar 25, 2018 3:45pm – 4:45pm
Conference:
SGO 2018
Authors:
Carin Espenschied, Heather Hampel, Ian M Frayling, Jessica Profato, Kory Jasperson, Patrick Reineke, Tina Pesaran, MA, MS, CGC, Virginia Speare
Collaborators:
  • Nearly half (47%) of all IHC results were discordant with germline MMR gene testing results.
  • The vast majority of these cases had abnormal MSI/IHC with no germline mutation identified.
  • These results may help guide clinicians on what to expect from multigene panel testing in patients with a particular MSI/IHC results and suggest scenarios where somatic mismatch repair gene testing may be useful.
Abstract