Functional and clinical characterization of variants of uncertain significance identifies a hotspot for inactivating missense variants in RAD51C

Amal Yussu, Anil Belur Nagaraj, Carolyn A Lumby, Celine M Vachon, Christopher A Haiman, Chunling Hu, Elizabeth Chao, Eric C. Polley, Fergus Couch, Gaofeng Cui, Gemma Montalban, Georges Mer, Hermela Shimelis, Holly Laduca, Huaizhi Huang, Irene Ong, Jacques Simard, Jean-Yves Masson, Jeffrey N Weitzel, Jie Na, Jill Dolinsky, John Weroha, Julie R Palmer, Katherine Nathanson, Kathleen S. Hruska, Kun Y Lee, Lauren R Teras, Lisa R Susswein, Maegan E. Roberts, Marcy E. Richardson, Megan L Marshall, Nicholas Boddicker, Peter Kraft, Rachid Karam, PhD, Rohan Gnanaolivu, Sara Lindström, Siddhartha Yadav, Song Yao, Steven N. Hart, Susan Hiraki, Susan L. Neuhausen, Susan M. Domchek, Tina Pesaran, MA, MS, CGC, Yuan-Ping Pang