Large-scale application of ClinGen-InSiGHT APC-specific ACMG/AMP variant classification criteria leads to substantial reduction in VUS

Alexandra Martins, Andreas Laner, Andrew Latchford, Carli Tops, Carlo Maj, Deborah Ritter, Elisabet Ognedal, Emadeldin Hassanin, Emily Nadeau, Ester Borras, Finlay A Macrae, Gabriel Capellá, Ian M Frayling, Isabel Spier, Johan de Dunnen, Karl Krahn, Khalid Mahmood, Marc S Greenblatt, Marcy Richardson, Margareta Nordling, Marta Pineda, Maurizio Genuardi, Sean V. Tavtigian, Sharon E. Plon, Stefan Aretz, Thomas v O Hansen, Tina Pesaran, MA, MS, CGC, Valeria Vasta, Victoria Beshay, Wencong Lyman Lin, Xiaoyu Yin, Xuemei Shi