Collaborator: Institut Curie

• Hereditary diffuse gastric cancer spectrum associated with germline CTNNA1 loss of function revealed by clinical and molecular data from 351 carrier families and over 37 000 non-carrier controls

• Understanding how gene-disease relationships can impact clinical utility: adaptations and challenges in hereditary cancer testing

• When clinical meets molecular: Why, when and how do CTNNA1 germline variants cause hereditary diffuse gastric cancer development

  April 2, 2026

• Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families

  Abstract Purpose To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. Methods We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis was used…