Collaborator: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University

• Rare Germline Pathogenic Mutations of DNA Repair Genes are Most Strongly Asssociated with Grade Group 5 Prostate Cancer

  Abstract Background Rare germline mutations in several genes, primarily DNA repair genes, have been proposed to predict worse prognosis of prostate cancer (PCa). Objective To compare the frequency of germline pathogenic mutations in commonly assayed PCa genes between high- and low-grade PCa in patients initially presenting with clinically localized disease. Design, setting, and participants A…