Functional and clinical characterization of variants of uncertain significance identifies a hotspot for inactivating missense variants in RAD51C

Chunling Hu, Anil Belur Nagaraj, Hermela Shimelis, Gemma Montalban, Kun Y Lee, Huaizhi Huang, Carolyn A Lumby, Jie Na, Lisa R Susswein, Maegan E. Roberts, Megan L Marshall, Susan Hiraki, Holly Laduca, Elizabeth Chao, Amal Yussu, Tina Pesaran, MA, MS, CGC, Susan L. Neuhausen, Christopher A Haiman, Peter Kraft, Sara Lindström, Julie R Palmer, Lauren R Teras, Celine M Vachon, Song Yao, Irene Ong, Katherine Nathanson, Jeffrey N Weitzel, Nicholas Boddicker, Rohan Gnanaolivu, Eric C. Polley, Georges Mer, Gaofeng Cui, Rachid Karam, PhD, Marcy E. Richardson, Susan M. Domchek, Siddhartha Yadav, Kathleen S. Hruska, Jill Dolinsky, John Weroha, Steven N. Hart, Jacques Simard, Jean-Yves Masson, Yuan-Ping Pang, Fergus Couch