Functional and clinical characterization of variants of uncertain significance identifies a hotspot for inactivating missense variants in RAD51C
Authors: Chunling Hu; Anil Belur Nagaraj; Hermela Shimelis; Gemma Montalban; Kun Y Lee; Huaizhi Huang; Carolyn A Lumby; Jie Na; Lisa R Susswein; Maegan E Roberts; Megan L Marshall; Susan Hiraki; Holly LaDuca; Elizabeth Chao; Amal Yussu; Tina Pesaran; Susan L Neuhausen; Christopher A Haiman; Peter Kraft; Sara Lindström; Julie R Palmer; Lauren R Teras; Celine M Vachon; Song Yao; Irene Ong; Katherine L Nathanson; Jeffrey N Weitzel; Nicholas Boddicker; Rohan Gnanaolivu; Eric C Polley; Georges Mer; Gaofeng Cui; Rachid Karam; Marcy E Richardson; Susan M Domchek; Siddhartha Yadav; Kathleen S Hruska; Jill Dolinsky; John Weroha; Steven N Hart; Jacques Simard; Jean-Yves Masson; Yuan-Ping Pang; Fergus J Couch
Collaborators: American Cancer Society; Beckman Research Institute of City of Hope; Boston University; GeneDx; Harvard T.H. Chan School of Public Health; Keck School of Medicine of USC; Latin American School of Oncology; Mayo Clinic; Ohio State University (OSU); Roswell Park Comprehensive Cancer Center; Université Laval; University of Chicago; University of Kansas Cancer Center; University of Pennsylvania; University of Southern California; University of Washington; University of Wisconsin - Madison