Challenges and approaches to calibrating patient phenotype as evidence for cancer gene variant classification under ACMG/AMP guidelines

Amal Yussuf, Amanda B. Spurdle, Cristina Fortuno, David Goldgar, Jessica L Mester, Jill Dolinsky, Kathleen S. Hruska, Michael Parsons, PhD, Paul A. James, Raymond C Chan, Robert O’Connor, Sean V. Tavtigian, Serra Kim, Susan Hiraki, Tina Pesaran, MA, MS, CGC