Variant reclassification in a large cardiogenetic testing cohort: The importance of disease specific variant classification criteria  

-95% of VUSs in this study were reclassified to LB/B
-Further emphasizes that patient management decisions should not be made based on a reported VUS and education on this point is crucial with more non-genetics providers order genetic testing 
-Many of the reclassifications were due to our laboratory’s CVD-tailored variant classification criteria and our continual work to improve variant classification tools
-Gene-disease-specific classification criteria can optimize accurate variant classification and decrease VUS rates