Psychiatric Genomics: Risks, Methods, and Convergence with Rare Disorders

In this webinar, we will summarize the current understanding of the transdiagnostic risks and genomic underpinnings across psychiatric disorders and how those estimates are obtained. We will review the ways in which we study common, psychiatric diseases including the genome-wide association study and outline numerous considerations when interpreting a GWAS, including trait definition, ancestry, predictive power, and sequencing platforms. We will review post-GWAS approaches including functional genomics methods such as expression quantitative trait loci (eQTL) mapping and potential clinical applications of polygenic risk scores. We end with examples from Dr. Signer’s research where rare loci and common genomic regions implicated in eating disorders converge. 

Level of instruction: Intermediate