Colon Pathology Characteristics in Li-Fraumeni Syndrome.

Li–Fraumeni syndrome (LFS) is a rare autosomal-dominant hereditary cancer syndrome associated with germline mutations in the TP53 tumor-suppressor gene. The lifetime risk of cancer is up to 70% in men and almost 100% in women.1 Studies continue to show that the tumor spectrum of TP53 mutation carriers is wider than previously thought and includes early onset colorectal cancer (CRC).2–4

• Authors: William Rengifo-Cam; Hailey M. Shepherd; Kory W. Jasperson; N. Jewel Samadder; Wade Samowitz; Sheryl R. Tripp; Joshua D. Schiffman; Wendy Kohlmann
• Journal: Clinical Gastroenterology and Hepatology
• Date: 2017 - Jun