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Colon Pathology Characteristics in Li-Fraumeni Syndrome.

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Date: November 28, 2017
Authors:
William Rengifo-Cam, Hailey M. Shepherd, Kory W. Jasperson, N. Jewel Samadder, Wade Samowitz, Sheryl R. Tripp, Joshua D. Schiffman, Wendy Kohlmann
Journal: Clinical Gastroenterology and Hepatology
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Li–Fraumeni syndrome (LFS) is a rare autosomal-dominant hereditary cancer syndrome associated with germline mutations in the TP53 tumor-suppressor gene. The lifetime risk of cancer is up to 70% in men and almost 100% in women.1 Studies continue to show that the tumor spectrum of TP53 mutation carriers is wider than previously thought and includes early onset colorectal cancer (CRC).2–4