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Moderate Risk Genes Matter: Multigene Testing for Hereditary Breast Cancer

Session:
#1224
Date:
Wednesday, Dec 6, 2017 5:00pm – 7:00pm
Conference:
SABCS 2017
Authors:
Carin Espenschied, Holly Laduca, Jessica Profato, Michelle Jackson

Poster-Discussion

  • Over 30,000 breast cancer cases were tested, 10.5% were positive for a germline mutation
  • 80.0% of the gene mutations identified (8.4% of all breast cancer patients) occurred in genes with NCCN® management guidelines for at least one cancer type
  • This large cohort indicates that approximately 3.9% and 6.6% of breast cancer patients have mutations in high and moderate risk genes, respectively. Though these values may shift as gene-specific breast cancer risks continue to be refined, it is clear that moderate risk genes play a significant role in breast cancer susceptibility
Abstract