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Expanding BRCA1/2 testing criteria to include other confirmed breast and ovarian cancer susceptibility genes

Session:
#1524
Date:
Saturday, Jun 2, 2018 1:15pm – 4:45pm
Conference:
ASCO 2018
Authors:
Amal Yussuf, Carrie Horton, Chunling Hu, Eric C. Polley, Fergus Couch, Hermela Shimelis, Holly Laduca, Jenna Lilyquist, Jill Dolinsky, Lily Hoang, Steven N. Hart, Virginia Speare
  • Breast cancer susceptibility gene mutations are detected in 8.6% of breast cancer patients undergoing multigene panel testing who meet BRCA1/2 testing criteria (3.4% in BRCA1/2 and 5.2% in other genes).
  • Ovarian cancer susceptibility gene mutations are detected in 13.0% of OC patients undergoing multigene panel testing (8.0% for BRCA1/2 and 5.0% in other genes).
  • Inclusion of additional risk genes increases detection rate for BC and OC patients meeting BRCA1/2 testing criteria by 152.9% and 62.5%, respectively
Abstract