Additional findings amongst relatives pursuing oncology multigene panel cascade testing

Presenting Author: Sarah Siddiqui, MS CGC

Take home points: 

1. Implementing cascade MGPT increases the overall positive rate, and approximately half of AFPVs are directly tied to medical management recommendations.
2. The majority of relatives with AFPVs impacting medical management had consistent phenotype or met criteria for the AFPV demonstrating the benefit of comprehensive family history collection and pre-test counseling.
3. However, nearly 25% of relatives had an AFPV without suggestive history that would impact their medical management.