Risks of triple negative breast cancer associated with cancer predisposition gene mutations.

Date:
Friday, Jun 3, 2016 2:00pm – 2:09pm
Conference:
ASCO 2016
Authors:
Fergus Couch, Holly Laduca, Elizabeth Chao, Jill Dolinsky, Margaret Akinhanmi, Hermela Shimelis, Emily Hallberg, Chunling Hu, Steven N. Hart, Raymond Moore, Huong Meeks, Robert Huether, David E. Goldgar

Multigene panel testing for hereditary cancer includes genes identified as hereditary breast and/or ovarian cancer (HBOC) genes despite limited data regarding the precise cancer risks associated with mutations in these genes. Here we report on risks of breast cancer and separately risks of triple negative breast cancer associated with mutations in 20 predisposition genes.