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Increased risk of HER2-positive breast cancer among germline CHEK2 mutation carriers with breast cancer.

Date:
Friday, Jun 3, 2016 3:00pm – 5:25pm
Conference:
ASCO 2016
Authors:
Andrea Forman, Jill Dolinsky, Virginia Speare, Chethan Ramamurthy, Raji Shameem, Rachel McFarland, Wafik S. El-Diery, Michael J. Hall, Mary Beryl Daly, Lori J. Goldstein, Elias Obeid

Checkpoint Kinase 2 (CHEK2) germline mutations have been linked to hereditary cancers, particularly breast cancer, with data suggesting a lower risk of cancer susceptibility for the I157T CHEK2 mutation. There are no data regarding the subtypes of breast cancer including HER2 expression/gene amplification in breast tumors associated with germline CHEK2 mutations.

Poster Abstract